Klinefelter sendromu ilk tan›mlanan kromozom anomalisi olup temel olarak hipergonadotropik hipogonadizm ve önükoid vücut yap›s› ile karakterizedir. S›kl› ¤›. ‘de tarif edilen Klinefelter sendromu hipogonadiz ve infertilitenin en sık tek nedenidir. Paternal mayoz hataları Klinefelter sendromunun yarısını oluştururken . Key words: Antisocial personality disorder, Klinefelter’s syndrome. ÖZET. Antisosyal kişilik bozukluğu ile karşımıza çıkan 18 yaşında Klinefelter’s sendromu tanısı.

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In addition to such numerical chromosomal abnormalities, we can rarely see structural chromosomal aberrations as well. During this period, patients often present themselves with the complaint of infertility. Cases of Klinefelter syndrome developed due to the errors in the stage of mitosis following the formation of the zygote are rare 7. A case of human intersexuality having a possible XXY sex-determining klinefelger.

Studies have been reported that certain diseases were more prevalent in patients with Klinefelter syndrome. In patients with mosaic form, serum Klinefeelter level is seen to be slightly higher, while serum testosterone levels are usually normal. The Klinefelter syndrome of testicular dysgenesis. Chromosome analysis of epididymal and testicular sperm in azoospermic patients undergoing ICSI.

In fact, studies showed that congenital malformations such as clinodactyly, cleft palate and inguinal hernia were seen more frequently in infants with Klinerelter syndrome than healthy male children Infants, whose fathers have Klinefelter syndrome, mostly have normal karyotype. Abramsky L, Chapple J. During delivery, nothing specific klinfeelter be observed in infants related with classic Klinefelter syndrome. Beside the problems such as a delay in speech and movement, learning difficulties, a delay in reading, abnormalities in cognitive functions like aggressiveness and non-compliance can be seen in those patients.


Anyone accessing the ” SITE ” with or without a fee whether they are a natural person or a legal identity is considered to agree these terms of use. In patients with Klinefelter syndrome, it has been shown that there is a mild increase in serum estradiol levels. Oral preparations may rarely have toxic effects to liver thus it is not preferred very often.

Turkiye Klinikleri Journal of Pediatrics

InJacobs and Strong stated that Klinefelter syndrome was a chromosomal disease and they were able to identify a 47,XXY chromosome structure created by an extra Klinefdlter chromosome causing this clinical picture 3. Klinefelter syndrome and its variants: However, in patients at their pre-pubertal period, this feature does not contribute much to the diagnosis.

Especially in patients with low levels of testosterone, testosterone replacement should be performed. There is no spermatogenesis in patients with Klinefelter syndrome, thus the possibility of fertility is considered to be very low in general. Intramuscular injections of testosterone enanthate or testosterone cypionate are the most commonly used testosterone replacement therapy agents.

File:Klinefelter’s Syndrome XXY – Wikimedia Commons

Seldom in Klinefelter syndrome patients, who had spermatozoa in their ejaculate, pregnancies were reported with ssndromu help of human chorionic gonadotropin therapy. These patients usually have problems in psychological adjustment.

Rec Prog Horm Res ; Hypogonadism was found to be the most important cause of bone mineral deficiency. These features are not usually clinically detectable at prepubertal period in patients with classic Klinefelter syndrome.

Please share the subjects you think may enrich our website or if there is any problem regarding our website. No relationship has been detected between the occurrence of gynecomastia and increase in estrogen. There are patients showing clinical signs at various levels klinefeltter well as patients showing no symptoms.


These injections are usually done within 3-week intervals. A practical guide to male hypogonadism in the primary care setting. Commitment to accuracy and legality of the published information, context, visual and auditory images provided by any ilinefelter party are under the full responsibility of the sendormu party. Some patients can be diagnosed at a very advanced age and some surviving patients may remain undiagnosed 4. The cause of this increase is thought to be as a result of an kliefelter testosterone aromatization Also, force majeure situations include but not limited to natural disasters, rebellion, war, strike, communication problems, infrastructure and internet failure, power cut and bad weather conditions.

Process List Turkish English. However, it should be kept in mind that this analysis can rarely be found normal. Another common laboratory finding in almost all of the patients with Klinefelter syndrome is serious reduction in the number of sendroomu.

InPlunkett and Barr, studied buccal mucosa cells of men with Klinefelter syndrome and described the pathognomonic appearance, nowadays called Barr body 2. Subscription and Public Relations Department Phone: The most noteworthy feature is the absence of testicular volume increase during adolescence.