KURNAKOV TEST PDF

The Kurnakov test, also known as Kurnakov’s reaction, is a chemical test that The test was devised by Soviet chemist Nikolai Semenovich Kurnakov. I’m trying to answer this question: However, I don’t fully understand the exact synthesis of the thiourea complexes. For one, I don’t understand. of substituted pyrimidines and their products from thiourea in Kurnakov’s reaction react with thiourea (tu) to give different products (Kurnakov’s test).

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Benjamin, New York,p. The Kurnakov test is sometimes used to detect transplatin in samples of the drug cisplatin. Senior staff scientist on specialty inorganic chemistrydoctor of chemical sciencesprofessorcorresponding member of kurnakkov ASacademici Kurnakov was born in NolinskKirov Oblast.

Stalin suppressed all opposition to his rule, committed the state ideology to Marxism—Leninism. Kurnakkov Journal of Chemistryvolume 8, pp. In his later years, he focused his work on platinum chemistry and platinum production.

Cis 1,2 dichlorocyclohexane 2D skeletal. The Kurnakov test is sometimes used to detect transplatin in samples of the drug cisplatin. Member feedback about Nikolay Dobrokhotov: Petersburg University where he studied under Lev Aleksandrovich Chugaev — Inhe graduated with honours from Moscow D.

By using this site, you agree to the Terms of Use and Privacy Policy. Some authors prefer the term trans influence to distinguish it from the kinetic effect, the discovery of the trans effect is attributed to Ilya Ilich Chernyaev, who recognized it and gave it a name in Nikolay Dobrokhotov was the eldest son in a family of 12 children.

Russian Journal of Inorganic Chemistry. This page was last edited on 25 Aprilat The ototoxicity of both the aminoglycosides and cisplatin may be related to their ability to bind to melanin in the stria vascularis of the inner ear or the generation of reactive oxygen species. Stretching by as much as 0. The first type of theory is primarily an electrostatic one that emphasises a weakening or labilisation of the trans bond, suggested by Chernyaev himself 19Nekrasov 27and Grinberg On the basis of transformation reactions, Werner assigned them the configurations:.

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Audiometric analysis may be necessary to assess the severity of ototoxicity. Less well known, however, is his role as one of the creators of refining technology in the Soviet precious metals industry. Almost every student of organic chemistry knows that most substitution reactions do not occur in a random manner, and in a similar manner, khrnakov reactions among kurnakkov compounds are not random.

The trans compound gives a colourless solution from which snow white needles of trans-[Pt tu 2 Cl 2 ] deposit on cooling.

Soviet war casualties accounted for the highest proportion of the conflict in the effort of acquiring the upper hand over Axis forces at battles such as Stalingrad. His name, of course, is inextricably linked with the trans effect and with numerous researches kurnaov the compounds of divalent and tetravalent platinum, especially those containing nitro groups.

This is a dose-limiting toxicity. After the death of his wife in his health deteriorated and he died kurna,ov a sanatorium in Barvikha on 19 March Kurnakov’s Contribution to Coordination Chemistry”. Kauffman, Platinum Metals Rev.

Kurnakov test – WikiVisually

Subsequently, the platnum cross-links two bases via displacement of the other chloride ligand. He also investigated substitution reactions of complexes of chromium, cobalt, tellurium, and osmium. Trans effect — In inorganic chemistry, the trans effect is the labilization of ligands that are trans to certain other ligands, which can thus be regarded as trans-directing ligands. Uses authors parameter link. Soviet scientists Revolvy Brain revolvybrain.

Inhe was appointed Professor at Leningrad University, and ukrnakovhe took charge of the Section for the Chemistry of Complex Compounds in the newly created Institute of General and Inorganic Chemistry of the U. Until his death on September 30,he remained at this institute, which was transferred kurnxkov Moscow in and underwent several changes in name through the years. He published his kurnakob paper on alum crystallization and sodium thioantimoniate in The hypocalcaemia seems to occur in those with low serum magnesium secondary to cisplatin, so it is not primarily due to the Cisplatin.

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Kurnakov Test on [Pt

Academician of the Academy of Sciences of the U. Soviet forces eventually captured Berlin inthe territory overtaken by the Red Army became satellite states of the Eastern Bloc.

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Kurnakov test

Upon treatment with thiourea, the trans dihalides give less soluble white products whereas the cis dihalides give more soluble yellow products. In his later years, he focused his work on platinum chemistry and he received several prizes, for example the Mendeleev Prize inthe Order of the Red Banner of Labour in and the Stalin Prize in A high performance liquid chromatographic application of kurnakow’s test”.

The test is still used to assay samples of the drug cisplatinbut it is mainly of pedagogical interest, as it illustrates the trans effect. The tst made it possible for the first time to plan systematic routes for carrying out inner-sphere substitution reactions in order to prepare platinum complexes in which all the ligands are different.

The test was devised by Soviet chemist Nikolai Semenovich Kurnakov. From tillhe was a director of this Institute.